Pharaoh/Cleo is very much like C3, Farming is a touch eaiser to manage once you get the hang of it, building monuments as Mouse said is huge, roadblocks make building housing blocks a little eaiser.
Zeus is all about defeating Gods and Monsters and building a city to do so. In my opinion building a zeus housing block is very easy and is not the central challenge of the game. Zeus/Posiden have eposodic goals very unlike C3, a set of goals might be, 3 trading partners, defeat a monster, 500 people in townhouses. For me the part of Zeus that is hardest to master is the complex relations your city must maintain with other cities.
I have just started playing Emperor, so far it is like Zeus in goals and inter-city relations, but is much improved in many ways; graphics, better challenge in building stable housing blocks, and feng shui!